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Antibodies Against Citrullinated Peptides

A Role in the Diagnosis of Rheumatoid Arthritis



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Sensitivity and Specificity Comparison Anti-CCP and RF

Slide 12

September 2008

In a study performed in our laboratory at the Mayo Clinic, we compared the sensitivity and the specificity of the second and third generation anti-CCP antibody assays with our net filametric assay for Rheumatoid factor. We looked at a population of healthy individuals as well as patients with Rheumatoid Arthritis and patients with other systemic Rheumatic diseases. The first item to point out is that the sensitivity of both anti-CCP antibody assays is comparable to Rheumatoid factor, all of which being approximately 80%.

The second item to mention is that the specificity of the anti-CCP antibodies is improved over Rheumatoid factor in both the healthy individuals and the patients with other connective tissue diseases. Using healthy individuals, the specificity of both anti-CCP antibody assays approaches close to 100%; however, this specificity appears to decrease slightly when evaluating patients with other connective tissue diseases. This may be due to the presence of overlap syndromes in some of these patients although further studies are needed to clarify this point.

Sensitivity and Specificity Comparison

 


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