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Warfarin Sensitivity Genotyping

Warfarin Metabolism

Slide 9

August 2008

There are two isomers of warfarin as I indicated earlier; the less active R-warfarin is metabolized as by a variety of cytochrome P450 enzymes encoded by several different CYP genes. These hydroxylate the R-warfarin derivatives, and then it is eliminated.

The S-warfarin, or the more active isomer, is metabolized predominately made by CYP2C9 enzyme which is encoded by the CYP2C9 gene. This hydroxylates the S-warfarin and it is also eliminated.

Warfarin Metabolism


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