Warfarin Sensitivity Genotyping
Warfarin and Bleeding Events
August 2008
Warfarin is right now one of the most common causes for Adverse Drug Reactions (ADR); it has actually topped the list for adverse drug reactions for drugs in the United States. There are approximately 177,000 ADRs annually; approximately 30,000 Emergency Department visits annually due to the warfarin. Three percent of those who were taking warfarin will experience a major bleed; minor bleeding events may be 6.6% or higher depending upon the study per year. And fatal bleeding events are estimated to be 0.6% total.
Risk for an ADR increase by alterations in the genes that encode the enzymes that metabolize warfarin and the target of warfarin inhibition.
Warfarin and Bleeding Events |
Jump to section:
- Introduction
- Warfarin
- Warfarin Anticoagulation
- Warfarin
- Warfarin Monitoring
- Therapeutic Graph
- INR Variability in a 74 Year-old Male
- Warfarin and Bleeding Events
- Warfarin Metabolism
- Polymorphisms and Warfarin Sensitivity
- Polymorphisms and Warfarin Sensitivity
- Summary of Polymorphisms and Warfarin Pharmacokinetics5
- CYP2C9 Association Study
- PGx-Guided Warfarin Dosing7
- Warfarin Pharmacodynamics
- Polymorphisms and Warfarin Sensitivity
- VKORC1 Promoter Polymorphism6
- CYP2C9 and VKORC1 Interaction8
- Genotype-guided Warfarin Dosing9
- Genotype-guided Dosing
- Summary
- Orthopedic Algorithm10
- Significant Warfarin Drug Interactions
- Differential Effect of Drugs
- Patient Case: Rapidly Increasing INR
- References
- Questions?
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