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Warfarin Sensitivity Genotyping

Warfarin and Bleeding Events

Slide 8

August 2008

Warfarin is right now one of the most common causes for Adverse Drug Reactions (ADR); it has actually topped the list for adverse drug reactions for drugs in the United States. There are approximately 177,000 ADRs annually; approximately 30,000 Emergency Department visits annually due to the warfarin. Three percent of those who were taking warfarin will experience a major bleed; minor bleeding events may be 6.6% or higher depending upon the study per year. And fatal bleeding events are estimated to be 0.6% total.

Risk for an ADR increase by alterations in the genes that encode the enzymes that metabolize warfarin and the target of warfarin inhibition.

Warfarin and Bleeding Events


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