Warfarin Sensitivity Genotyping
Therapeutic Graph
August 2008
What I have shown here is the odds ratio from varying complications from warfarin therapy. In the middle between INR 2 and 3 is the therapeutic range.
Below 2 there is an exponential increase of odds of having a thrombotic stroke. Above 3 there is an increase risk for having cerebrovascular bleeding; so the goal is to maintain the patient as closely as possible between an INR of 2 and 3 in most applications.
With some patients who have older heart valves they might require an INR as going as high as 3.5.
Therapeutic Graph |
Jump to section:
- Introduction
- Warfarin
- Warfarin Anticoagulation
- Warfarin
- Warfarin Monitoring
- Therapeutic Graph
- INR Variability in a 74 Year-old Male
- Warfarin and Bleeding Events
- Warfarin Metabolism
- Polymorphisms and Warfarin Sensitivity
- Polymorphisms and Warfarin Sensitivity
- Summary of Polymorphisms and Warfarin Pharmacokinetics5
- CYP2C9 Association Study
- PGx-Guided Warfarin Dosing7
- Warfarin Pharmacodynamics
- Polymorphisms and Warfarin Sensitivity
- VKORC1 Promoter Polymorphism6
- CYP2C9 and VKORC1 Interaction8
- Genotype-guided Warfarin Dosing9
- Genotype-guided Dosing
- Summary
- Orthopedic Algorithm10
- Significant Warfarin Drug Interactions
- Differential Effect of Drugs
- Patient Case: Rapidly Increasing INR
- References
- Questions?
External
link
PDF
document
Excel
document
Word
document