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Warfarin Sensitivity Genotyping

Therapeutic Graph

Slide 6

August 2008

What I have shown here is the odds ratio from varying complications from warfarin therapy. In the middle between INR 2 and 3 is the therapeutic range.

Below 2 there is an exponential increase of odds of having a thrombotic stroke.  Above 3 there is an increase risk for having cerebrovascular bleeding; so the goal is to maintain the patient as closely as possible between an INR of 2 and 3 in most applications.

With some patients who have older heart valves they might require an INR as going as high as 3.5.

Therapeutic Graph


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