Warfarin Sensitivity Genotyping
Significant Warfarin Drug Interactions
August 2008
Now we also have to take into consideration not just the genotyping but significant drug-drug interactions with warfarin. There are several that should be mentioned because they marked changes in the INR in just a few days. Trimethoprim-Sulfamethoxazole will increase the INR by approximately 50% in 2-3 days if given to a patient, Metronidazole, another -azole antibiotic, will increase the INR greater than 50% in roughly 2- 3 days. Cimetidine increases the INR in almost all patients receiving warfarin and it is recommended that they be switched to other antacids.
Significant Warfarin Drug Interactions |
Jump to section:
- Introduction
- Warfarin
- Warfarin Anticoagulation
- Warfarin
- Warfarin Monitoring
- Therapeutic Graph
- INR Variability in a 74 Year-old Male
- Warfarin and Bleeding Events
- Warfarin Metabolism
- Polymorphisms and Warfarin Sensitivity
- Polymorphisms and Warfarin Sensitivity
- Summary of Polymorphisms and Warfarin Pharmacokinetics5
- CYP2C9 Association Study
- PGx-Guided Warfarin Dosing7
- Warfarin Pharmacodynamics
- Polymorphisms and Warfarin Sensitivity
- VKORC1 Promoter Polymorphism6
- CYP2C9 and VKORC1 Interaction8
- Genotype-guided Warfarin Dosing9
- Genotype-guided Dosing
- Summary
- Orthopedic Algorithm10
- Significant Warfarin Drug Interactions
- Differential Effect of Drugs
- Patient Case: Rapidly Increasing INR
- References
- Questions?
External
link
PDF
document
Excel
document
Word
document