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Warfarin Sensitivity Genotyping


Slide 21

August 2008

A summary if a warfarin dose is too great for a person’s genotype then this will increase the plasma warfarin exposure or the area under the curve over time. The increased exposure to warfarin will result in a higher INR in that individual, the higher INR increases risk for bleeding, the higher the INR the greater the risk and this becomes significant for those who have INRs above six. Genotyping for CYP2C9 and VKORC1 permits warfarin dose adjustments prior to dosing or after the first few doses.



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