Warfarin Sensitivity Genotyping
Summary
August 2008
A summary if a warfarin dose is too great for a person’s genotype then this will increase the plasma warfarin exposure or the area under the curve over time. The increased exposure to warfarin will result in a higher INR in that individual, the higher INR increases risk for bleeding, the higher the INR the greater the risk and this becomes significant for those who have INRs above six. Genotyping for CYP2C9 and VKORC1 permits warfarin dose adjustments prior to dosing or after the first few doses.
Summary |
Jump to section:
- Introduction
- Warfarin
- Warfarin Anticoagulation
- Warfarin
- Warfarin Monitoring
- Therapeutic Graph
- INR Variability in a 74 Year-old Male
- Warfarin and Bleeding Events
- Warfarin Metabolism
- Polymorphisms and Warfarin Sensitivity
- Polymorphisms and Warfarin Sensitivity
- Summary of Polymorphisms and Warfarin Pharmacokinetics5
- CYP2C9 Association Study
- PGx-Guided Warfarin Dosing7
- Warfarin Pharmacodynamics
- Polymorphisms and Warfarin Sensitivity
- VKORC1 Promoter Polymorphism6
- CYP2C9 and VKORC1 Interaction8
- Genotype-guided Warfarin Dosing9
- Genotype-guided Dosing
- Summary
- Orthopedic Algorithm10
- Significant Warfarin Drug Interactions
- Differential Effect of Drugs
- Patient Case: Rapidly Increasing INR
- References
- Questions?
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