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Warfarin Sensitivity Genotyping



Polymorphisms and Warfarin Sensitivity

Slide 11

August 2008

A second more deleterious allele designated as CYP2C9*3 has a substitution of a leucine for isoleucine caused by a change in nucleotide at 1075 of an adenine to a cytosine. Enzymatic activity is reduced to approximately 10% of the normal the *1 wild type with no polymorphisms. The allelic frequency once again is population-dependent with the highest frequencies again found in Northern European white populations of between 6% and 10% frequency.

So these are common changes in the genes that cause frequent changes in the amount of activity in the CYP2C9 protein.

Polymorphisms and Warfarin Sensitivity

 


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