Warfarin Sensitivity Genotyping
Polymorphisms and Warfarin Sensitivity
August 2008
There are common polymorphisms in the CYP 2C gene that cause amino acid substitutions in the protein that are encoded by the gene. The alleles are designated by a star or asterisks followed by a number, the first one CYP2C9*2 has a substitution of a cystine for an arginine which is encoded at nucleotide 430, by a change from a cytosine to a thymidine. This reduces the enzymatic activity in the protein by about 50% for the metabolism of S-warfarin as compared to the wild type or normal which has no polymorphisms. The allele frequency for this particular polymorphism *2 is population dependent. The highest frequency is found in Northern European white populations, which is estimated between 8% and 13% of the total population.
Polymorphisms and Warfarin Sensitivity |
Jump to section:
- Introduction
- Warfarin
- Warfarin Anticoagulation
- Warfarin
- Warfarin Monitoring
- Therapeutic Graph
- INR Variability in a 74 Year-old Male
- Warfarin and Bleeding Events
- Warfarin Metabolism
- Polymorphisms and Warfarin Sensitivity
- Polymorphisms and Warfarin Sensitivity
- Summary of Polymorphisms and Warfarin Pharmacokinetics5
- CYP2C9 Association Study
- PGx-Guided Warfarin Dosing7
- Warfarin Pharmacodynamics
- Polymorphisms and Warfarin Sensitivity
- VKORC1 Promoter Polymorphism6
- CYP2C9 and VKORC1 Interaction8
- Genotype-guided Warfarin Dosing9
- Genotype-guided Dosing
- Summary
- Orthopedic Algorithm10
- Significant Warfarin Drug Interactions
- Differential Effect of Drugs
- Patient Case: Rapidly Increasing INR
- References
- Questions?
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