Free Light Chains & Monoclonal Gammopathies
Impact on Diagnostic Panels
Monoclonal Serum Proteins: Newly Diagnosed Multiple Myeloma (n=1027)
August 2008
Although Multiple Myeloma is a malignancy with a large number of colonel plasma cells and should be easy to detect by these assays. This slide points out the problem. Approximately, 75% of myeloma patients secrete intact immunoglobulins that will have large M-spikes. But approximately, 25% secrete only light chains or nothing at all.
Monoclonal Serum Proteins |
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- Introduction
- Diagnostic Tests
- Mayo Clinic 1960-2003
- Plasma Cell Proliferative Disorders
- Serum Protein Electrophoresis & Immunofixation Electrophoresis
- Serum Protein Electrophoresis & Immunofixation Electrophoresis
- Monoclonal Serum Proteins: Newly Diagnosed Multiple Myeloma (n=1027)
- Serum Protein Electrophoresis & Immunofixation Electrophoresis
- Urine Protein Electrophoresis & Immunofixation Electrophoresis
- Intact Immunoglobulin/Free Light Chain
- FLC Reference Range
- Diagnoses for 428 Patients Selected for Urine Monoclonal Protein
- Serum PEL & IFE Results: 428 Pts with Urine Monoclonal Protein
- Laboratory Results: 428 Patients with Monoclonal Urinary Protein
- Potential Savings
- Uses of Serum Free Light Chain Assay
- Diagnostic Test Panel for Suspected Monoclonal Gammopathies
- Questions?
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