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Free Light Chains & Monoclonal Gammopathies

Impact on Diagnostic Panels

Serum Protein Electrophoresis & Immunofixation Electrophoresis

Slide 6

August 2008

This next slide is an analysis of serum from a patient with multiple myeloma. On the PEL gel we see a dense discreet band representing the monoclonal immunoglobulin. And on the IFE gel we see this monoclonal protein has an IgG heavy chain and kappa light chain. So this patient has a monoclonal plasma self-proliferative disorder that is secreting an IgG kappa molecule.

The PEL also allows us to quantitate the amount of this protein. And from the large M-Spike we can predict that this patient most likely has multiple myeloma and we can monitor the affects of therapy by monitoring the size of the M-Spike. These are straight forward assays; the problem is that not all monoclonal gammopathies are this obvious on serum PEL & IFE.

Serum Protein Electrophoresiss


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