Free Light Chains & Monoclonal Gammopathies
Impact on Diagnostic Panels
Mayo Clinic 1960-2003
August 2008
There are at least a dozen different plasma cell proliferative disorders. On this slide I’ve listed the incidents of these in our Mayo Clinic practice. By far the most common disorder is monoclonal gammopathy of undetermined significance or MGUS. This is a premalignant condition and has no clinical symptoms; no anemia, no renal disease, no bone lesions. This is followed in incidence by other diseases such as multiple myeloma or primary amyloidosis or macroglobulinemia. All of these diseases listed here will have different clinical presentations and may require different treatments.
Mayo Clinic 1960-2003 |
Jump to section:
- Introduction
- Diagnostic Tests
- Mayo Clinic 1960-2003
- Plasma Cell Proliferative Disorders
- Serum Protein Electrophoresis & Immunofixation Electrophoresis
- Serum Protein Electrophoresis & Immunofixation Electrophoresis
- Monoclonal Serum Proteins: Newly Diagnosed Multiple Myeloma (n=1027)
- Serum Protein Electrophoresis & Immunofixation Electrophoresis
- Urine Protein Electrophoresis & Immunofixation Electrophoresis
- Intact Immunoglobulin/Free Light Chain
- FLC Reference Range
- Diagnoses for 428 Patients Selected for Urine Monoclonal Protein
- Serum PEL & IFE Results: 428 Pts with Urine Monoclonal Protein
- Laboratory Results: 428 Patients with Monoclonal Urinary Protein
- Potential Savings
- Uses of Serum Free Light Chain Assay
- Diagnostic Test Panel for Suspected Monoclonal Gammopathies
- Questions?
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