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Supplemental Newborn Screening by MS/MS-Based Second-Tier Testing

Impact of Second-Tier Testing on Performance of Newborn Screening by MS/MS at Mayo Clinic

Slide 15

July 2008

What is the impact of second-tier testing on the performance of newborn screening by tandem mass spectrometry at the Mayo Clinic? We have a very low false-positive rate  of 0.07%, a high-positive predictive value of 39%, a positive detection rate, where we find one affected case in 2,249 babies screened, there are very few unnecessary follow-up evaluations, basically 1.4 per week in 100,000 births. This, as you will recognize, is the "best case scenario."

Impact of Second-Tier Testing


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