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Supplemental Newborn Screening by MS/MS-Based Second-Tier Testing

Costs of False-Positive NBS Results

Slide 14

July 2008

Coming back to our example for screening for congenital adrenal hyperplasia in Minnesota, if we look at the 2007 data and look at it with the second-tier test that was actually implemented, with the second-tier test, the false-positive results were not 710, but only 41. The false-positive rate was only 0.06% as opposed to almost 1%.  The cost of clinical follow-up was reduced to $38,000; however, one has to pay for the second-tier test. Overall, the total follow-up cost is not $600,000, but $62,000 with a savings of 89%.

Costs of False-Positive Results


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