Supplemental Newborn Screening by MS/MS-Based Second-Tier Testing

Costs of False-Positive NBS Results

July 2008

Let’s get back to the example of congenital adrenal hyperplasia screening in Minnesota. If you look at the numbers for 2007, there are 710 false-positive results, or a false-positive rate of 1%. The cost of the clinical follow-up would have been about $600,000 and this is without a second-tier test.

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Costs of False-Positive Results

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Jump to section:

• Introduction
• What is Newborn Screening?
• Evolution of Newborn Screening
• ACMG* Uniform Panel
• MS/MS Impact on Newborn Screening
• Newborn Screening Performance in the USA (MS/MS)
• Costs of False-Positive NBS Results
• Newborn Screening in Minnesota
• MN Newborn Screening Program
• Costs of False-Positive NBS Results
• What is Second-Tier Testing?
• Second-Tier Testing is Performed for the Following "Problem" Analytes
• Why Second-Tier Testing?
• Costs of False-Positive NBS Results
• Impact of Second-Tier Testing on Performance of Newborn Screening by MS/MS at Mayo Clinic
• Questions?