Laboratory Testing for Hepatitis B

Anti-HBs - Qualitative vs Quantitative

June 2008

I want to mention briefly about the indications and use of qualitative versus quantitative Hepatitis B surface antibody. The qualitative Hepatitis B surface antigen is mainly indicated to stage Hepatitis B infection, to determine whether it’s past infection versus chronic. As in the case of chronic Hepatitis B, the surface antibody would be absent.

It is also useful to determine immunity status to Hepatitis B infection because when the result is positive, it is indicated that it’s greater than or equal to 10 miU/mL which is the World Health Organization standard for conferring protection from Hepatitis B infection.

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• Introduction
• Patient Case
• Patient Case
• Acute HBV Infection with Recovery
• Progression to Chronic HBV Infection
• Serologic Markers
• Serologic Methods
• Diagnosis
• Anti-HBs - Qualitative vs Quantitative
• Anti-HBs - Qualitative vs Quantitative
• Molecular Testing
• HBV DNA Quantification Assays
• Patient Case
• Chronic Hepatitis B Therapeutic Options
• Patient Case
• Virologic Breakthrough During Rx for CHB
• HBV Genotyping and Drug Resistance Tests
• HBV Resistance Mutations
• Patient Case
• Summary
• Questions?
• Disclosure