Laboratory Testing for Hepatitis B

Diagnosis

June 2008

Diagnosis of Hepatitis B should be based on the patient’s medical history, risk of exposure and system complex along with evidence of abnormality in physical examination and other chemistry laboratory tests.

Here is a table of the various combinations of serologic markers for those with acute, chronic carrier or previous infections due to Hepatitis B. Of note is that Hepatitis B core IgM antibody is present only during the acute infection phase and Hepatitis B E antigen can be present or absent during chronic Hepatitis B stage. In the case of the active viral replication of chronic Hepatitis B, the E antigen is positive whereas those with minimal or inactive viral replication but still has positive Hepatitis B surface antigen will have negative E antigen.

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Diagnosis

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Jump to section:

• Introduction
• Patient Case
• Patient Case
• Acute HBV Infection with Recovery
• Progression to Chronic HBV Infection
• Serologic Markers
• Serologic Methods
• Diagnosis
• Anti-HBs - Qualitative vs Quantitative
• Anti-HBs - Qualitative vs Quantitative
• Molecular Testing
• HBV DNA Quantification Assays
• Patient Case
• Chronic Hepatitis B Therapeutic Options
• Patient Case
• Virologic Breakthrough During Rx for CHB
• HBV Genotyping and Drug Resistance Tests
• HBV Resistance Mutations
• Patient Case
• Summary
• Questions?
• Disclosure