Laboratory Testing for Hepatitis B

Serologic Markers

June 2008

Next we will review the serologic markers. As I mentioned, the Hepatitis B surface antigen is a reflection of acute or chronic infection. The Hepatitis B surface antibody, which can be measured qualitatively or quantitatively, is a reflection of either recent or past infection, but is also present in successful immunity resulting from Hepatitis B immunization.

Hepatitis B core IgM antibody is only present during the acute infection, but the Hepatitis B core total antibodies are present in both acute and past infection.

Hepatitis B E antigen is present in chronic carriers with active viral replication whereas the Hepatitis B E antibody is present in either chronic carriers with minimal viral replication or those with past infection.

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Serologic Markers

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Jump to section:

• Introduction
• Patient Case
• Patient Case
• Acute HBV Infection with Recovery
• Progression to Chronic HBV Infection
• Serologic Markers
• Serologic Methods
• Diagnosis
• Anti-HBs - Qualitative vs Quantitative
• Anti-HBs - Qualitative vs Quantitative
• Molecular Testing
• HBV DNA Quantification Assays
• Patient Case
• Chronic Hepatitis B Therapeutic Options
• Patient Case
• Virologic Breakthrough During Rx for CHB
• HBV Genotyping and Drug Resistance Tests
• HBV Resistance Mutations
• Patient Case
• Summary
• Questions?
• Disclosure