Laboratory Testing for Hepatitis B

Progression to Chronic HBV Infection

June 2008

For the minority of patients, namely adults who get Hepatitis B infection, they present with this serologic course in which the surface antigen is present and persists for years, and that’s the definition of chronic Hepatitis B or Hepatitis B carrier. The Hepatitis B E antigen is also present and persistent, but eventually, with immune tolerance and resolution of the infection they will convert to anti-Hepatitis B E antibody.

Note that Hepatitis B DNA (shown in the blue bar) is present and persists as long as the surface antigen is positive.

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Progression to Chronic HBV

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Jump to section:

• Introduction
• Patient Case
• Patient Case
• Acute HBV Infection with Recovery
• Progression to Chronic HBV Infection
• Serologic Markers
• Serologic Methods
• Diagnosis
• Anti-HBs - Qualitative vs Quantitative
• Anti-HBs - Qualitative vs Quantitative
• Molecular Testing
• HBV DNA Quantification Assays
• Patient Case
• Chronic Hepatitis B Therapeutic Options
• Patient Case
• Virologic Breakthrough During Rx for CHB
• HBV Genotyping and Drug Resistance Tests
• HBV Resistance Mutations
• Patient Case
• Summary
• Questions?
• Disclosure