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Laboratory Testing for Hepatitis B

Acute HBV Infection with Recovery

Slide 4

June 2008

Let’s review what we know about the typical serologic course of patients with acute Hepatitis B. In the majority of patients, i.e., 95% or more of adults infected with Hepatitis B, they present with this typical serologic profile in which the surface antigen becomes detectable first at about four weeks after exposure and at the same time there is detectable serum Hepatitis B DNA. This is followed by the appearance of anti-Hepatitis B core IgM indicated in the light orange line and of course anti-Hepatitis B core total antibodies which includes IgM is elevated at the same time.

Once the disease is resolved, the surface antigen disappear by about six months after exposure, and then there is a period of about eight weeks during which only Hepatitis B core IgM is detectable before the appearance of anti-Hepatitis B surface antibody. Note that the Hepatitis B E antigen is present during the acute phase of the infection and once their symptoms resolve then patients here will convert to anti-Hepatitis B E antibody.

Infection with Recovery


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