Laboratory Testing for Hepatitis B

Patient Case

June 2008

Let’s look at a patient case of a 55 year-old Asian American woman who immigrated to the United States 15 years ago. She presented to her primary physician with fatigue and a history of jaundice 25 years ago. Physical examination of this patient did not reveal any abnormality, but she was found to have a serum alanine aminotransferase level of 85 U/L.

How could the care provider rule out the possibility of chronic viral hepatitis in this patient?

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Jump to section:

• Introduction
• Patient Case
• Patient Case
• Acute HBV Infection with Recovery
• Progression to Chronic HBV Infection
• Serologic Markers
• Serologic Methods
• Diagnosis
• Anti-HBs - Qualitative vs Quantitative
• Anti-HBs - Qualitative vs Quantitative
• Molecular Testing
• HBV DNA Quantification Assays
• Patient Case
• Chronic Hepatitis B Therapeutic Options
• Patient Case
• Virologic Breakthrough During Rx for CHB
• HBV Genotyping and Drug Resistance Tests
• HBV Resistance Mutations
• Patient Case
• Summary
• Questions?
• Disclosure