Laboratory Testing for Hepatitis B

HBV Resistance Mutations

June 2008

The literature has shown that individuals with HBV virus showing different genotypic resistance mutations at these sites confer resistance to these drugs.

Here in the pink color, the four resistance mutations codons confer resistance to Lamivudine; the green show resistance to Adefovir; the blue resistance to Entecavir; and the light purple are resistance mutation codons to Telbivudine. Lastly, the black colored mutation confers resistance to Telbivudine.

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HBV Resistance Mutations

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• Introduction
• Patient Case
• Patient Case
• Acute HBV Infection with Recovery
• Progression to Chronic HBV Infection
• Serologic Markers
• Serologic Methods
• Diagnosis
• Anti-HBs - Qualitative vs Quantitative
• Anti-HBs - Qualitative vs Quantitative
• Molecular Testing
• HBV DNA Quantification Assays
• Patient Case
• Chronic Hepatitis B Therapeutic Options
• Patient Case
• Virologic Breakthrough During Rx for CHB
• HBV Genotyping and Drug Resistance Tests
• HBV Resistance Mutations
• Patient Case
• Summary
• Questions?
• Disclosure