Laboratory Testing for Hepatitis B

Virologic Breakthrough During Rx for CHB

June 2008

We know from natural history of anti-HBV treatment that there is emergence of resistance in the HBV virus after antiviral treatment is started and this emergence of resistance can be detected using molecular methods looking at genotypic resistance in the target gene of these drugs. This is followed by a virologic breakthrough which in this case meaning that the serum HBV DNA will rise and when there is full virologic breakthrough, then we will see the HBV DNA level returns to baseline, even when it’s being treated.

This is in contrast to the Wild-type HBV virus indicated in the green line.

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Virologic Breakthrough

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Jump to section:

• Introduction
• Patient Case
• Patient Case
• Acute HBV Infection with Recovery
• Progression to Chronic HBV Infection
• Serologic Markers
• Serologic Methods
• Diagnosis
• Anti-HBs - Qualitative vs Quantitative
• Anti-HBs - Qualitative vs Quantitative
• Molecular Testing
• HBV DNA Quantification Assays
• Patient Case
• Chronic Hepatitis B Therapeutic Options
• Patient Case
• Virologic Breakthrough During Rx for CHB
• HBV Genotyping and Drug Resistance Tests
• HBV Resistance Mutations
• Patient Case
• Summary
• Questions?
• Disclosure