Laboratory Testing for Hepatitis B

Patient Case

June 2008

Our patient was monitored closely every three months with her serum HBV DNA levels. As you can see form the slide, she had a good response three months into therapy with a decline in her serum DNA from 8,500,000 to 5,100 IU/mL, and her serum DNA HBV units were undetectable at six and nine months. Interestingly, by 12 months into mono therapy with Entecavir, there was a reemergence of viral DNA to 1,050 IU.

So the question posed by her treating physician is “What could be the cause(s) of the detectable HBV DNA level in serum at 12 months of therapy?”

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Jump to section:

• Introduction
• Patient Case
• Patient Case
• Acute HBV Infection with Recovery
• Progression to Chronic HBV Infection
• Serologic Markers
• Serologic Methods
• Diagnosis
• Anti-HBs - Qualitative vs Quantitative
• Anti-HBs - Qualitative vs Quantitative
• Molecular Testing
• HBV DNA Quantification Assays
• Patient Case
• Chronic Hepatitis B Therapeutic Options
• Patient Case
• Virologic Breakthrough During Rx for CHB
• HBV Genotyping and Drug Resistance Tests
• HBV Resistance Mutations
• Patient Case
• Summary
• Questions?
• Disclosure