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Serologic Diagnosis of Lyme Disease

Lyme Disease - Serologic Assays, cont.

Slide 13

May 2008

A common question following a result profile such as this is whether any further follow-up testing should be performed. For those patients testing positive by IgM Western blot alone, the general recommendation is to repeat serologic testing on a new specimen after 14-21 days. After this time, we should be able to demonstrate seroconversion of IgG which would then provide strong support of evidence of infection.

A few more points regarding Lyme Western blot. If testing is performed within 4 weeks of symptom onset, it is recommended that both IgM and IgG Western blot be performed. However, in patients with disease duration of greater than 1 month, IgM Western blot should not be performed. A positive IgM alone in this setting should not be used to diagnose infection due to the increased possibility of false positive results during the later stages of disease.

Serologic Assays, cont.


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