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Serologic Diagnosis of Lyme Disease

Lyme Disease - Serologic Assays, cont.

Slide 11

May 2008

As with the screening test, the sensitivity of Lyme Western blot is also dependent on the stage of the disease when testing is performed. During Stage 1, Western blot may demonstrate a sensitivity of 20%-50% with the majority of antibody detected being of the IgM class. In stages 2 and 3, of the disease the sensitivity of Western blot may increase to 70%-100% and we typically observe a switch in the prevalence of antibody to that of the IgG class.

It is important to point out that although a positive IgM Western blot generally indicates recent infection IgM class antibodies may persist for months to years following infection and because of this a positive IgM does not always serve as an indicator of recent acute infection.

Serologic Assays, cont.


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