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Serologic Diagnosis of Lyme Disease

Lyme Disease - Serologic Assays, cont.

Slide 10

May 2008

As we’ve already reviewed, specimens testing positive or equivocal by the screening method should be tested by Western blot. Lyme Western blot assays test for IgM and IgG class antibodies to Borrelia burgdorferi.  Western blot is considered a supplementary serologic approach and not confirmatory due to the potential for false positives and inter and intra laboratorial result variability with this method.

As we’ve discussed, the result of Western blot should be interpreted according to the current CDC criteria and testing by Western blot is not recommended in those patients testing negative by the screen EIA.

Serologic Assays, cont.


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