Laboratory Testing for Hepatitis C

Patient Case

April 2008

Our patient was found to have a positive HCV Total Antibody by a chemiluminescence immunoassay, which is the method used here at Mayo Medical Laboratories. With a signal-to-cutoff ratio of 15.1 for enzyme immunoassay and, any signal-to-cutoff greater than 1 is considered positive. The value of the ratios do not necessarily correlate with the amount of antibodies present, but in general, the higher the signal-to-cutoff ratio value, the more antibodies are usually detected in the specimen.

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• Introduction
• Patient Case
• Hepatitis C: Diagnostic Approach
• Acute Hepatitis C with Recovery
• Acute Hepatitis C with Progression to Chronic Infection
• Hepatitis C: Serologic Assays
• HCV Antigens Used in EIAs and CIAs for Detecting HCV Total Antibodies
• Patient Case
• Laboratory Algorithm
• Comparison of PCR, TMA, and bDNA
• Hepatitis C: Molecular Assays
• Hepatitis C: Molecular Tests
• Interpretation of Laboratory Test Results for HCV Infection
• Patient Case
• Hepatitis C: Genotyping Assays
• Patient Case
• Questions?