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Laboratory Testing for Hepatitis C

Acute Hepatitis C with Progression to Chronic Infection

Slide 5

April 2008

For the remaining three-quarters of individuals infected with Hepatitis C virus, they follow this typical serologic course which is one of chronic infection. The Hepatitis C RNA persists in the blood although at some time points, they may be undetectable because of low viral replication indicated by the interrupted red line. HCV antibodies appear around the same time as those who did recover, which is 2-3 months from infection. Symptoms appear again coinciding with the peak of serum ALT but here because of persistence of viral replication and continued inflammation of the liver, the serum ALT levels fluctuate over time indicated in the yellow line.

Acute HCV Progression to Chronic Infection


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