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Kikuchi Disease

Published: December 2012

Hot Topic Q&A is an opportunity for viewers to submit questions to the Hot Topic presenter. The opportunity to submit questions for this topic is now closed.

The following questions were submitted by viewers and answered by the presenter, Dragan Jevremovic, MD, PhD, Assistant Professor of Laboratory Medicine and Pathology and Co-Director of the Cell Kinetics Laboratory in the Division of Hematopathology, at Mayo Clinic in Rochester, MN.

Questions are presented as submitted (unedited).

  1. When do I follow-up with a patient with Kikuchi disease after resolution, to rule out SLE? What is the confirmatory test to diagnose this disease?

    Clinical correlation is essential in distinguishing Kikuchi disease (KD) from systemic lupus erythematosus (SLE). The diagnosis of SLE requires specific criteria as outlined by the American College of Rheumatology and these should be absent in KD cases. There are no specific criteria for follow-up of patients after resolution of Kikuchi disease, in the absence of lymphadenopathy or systemic symptoms. Our clinical colleagues would follow-up patients with a visit every 6 months for 1 to 2 years, without any lab testing if there are no symptoms.