Clopidogrel Platelet Function Tests
Caveats and Controversies
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Clopidogrel, also known as Plavix, is an antiplatelet prodrug used to block platelet activation and aggregation and inhibit thrombosis. The drug is metabolized in the liver by the enzyme CYP2C19 and polymorphisms of the CYP2C19 gene influence enzyme function and drug metabolism. Platelet functions studies can determine the drug’s effect and genetic testing is available to determine which polymorphisms are present in the patient’s genes. Both may be important in management of patients treated with clopidogrel.
- Gretchen Johns, MD, Laboratory Section Director for Coagulation and Medical Director for the Department of Laboratory Medicine and Pathology at Mayo Clinic in Jacksonville, Florida.
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- 2C19S/60439 Cytochrome P450 2C19 Genotype by Sequence Analysis
- 2C19O/60335 Cytochrome P450 2C19 Genotype by Sequence Analysis, Saliva
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