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Von Willebrand Disease (VWD)
Part 3: VWF Activity Assay

A New von Willebrand Factor Activity Assay and Testing Algorithm

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June 2011

Von Willebrand disease (VWD) is the most common of the inherited bleeding disorders. Plasma von Willebrand factor (VWF) activity is used in conjunction with VWF antigen and factor VIII coagulant activity to diagnosis VWD, differentiate VWD subtypes, and differentiate VWD from hemophilia A.

This is the third in a four-part series on von Willebrand disease, and is also included in the series on test utilization.


  • Dong Chen, MD, PhD, Co-director of the Special Coagulation Laboratory at Mayo Clinic in Rochester, Minnesota.

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The von Willebrand Disease (VWD) Series

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  • Hematologists
  • Coagulationists
  • Cardiologists

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