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Supplemental Newborn Screening by MS/MS-Based Second-Tier Testing

July 2008

Dr. Matern discusses the use of second-tier testing to reduce the number of false-positive results in newborn screening. This is accomplished using mass spectrometry technology. Also discussed: the unique partnership between Mayo Clinic and the Minnesota Department of Health is credited with reducing the number of false-positive test results, the cost of unnecessary follow-up testing, and parental anxiety for Minnesota parents.


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