Human Papillomavirus Molecular Detection with Genotyping
Published: January 2014
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The following questions were submitted by viewers and answered by the presenter, Matthew Binnicker, PhD, Director of the Clinical Virology Laboratory in the Division of Clinical Microbiology at Mayo Clinic in Rochester, Minnesota.
Questions are presented as submitted (unedited).
- If a specimen is submitted using the SurePath (SHPV) collection medium outside of the new 14 day stability window will the test be performed or cancelled?
Mayo Medical Laboratories has demonstrated that samples collected into SurePath media are stable for up to 14 days. If a sample is received >14 days past its collection date, the test through Mayo Medical Laboratories will be cancelled.
- For the US poor or countries with limited medical resources, could HPV 16/18 be the stand alone screen? Or the gateway screen to cervical cancer monitoring? Is it cost effective? I feel that PAP testing is subjective and unreliable.
HPV nucleic acid amplification tests (NAAT) are being considered as a first-line screening test. One manufacturer, Roche Diagnostics, has submitted data to the FDA for consideration of the Roche HPV assay as a front-line screening test. If this is approved, it is likely that samples testing positive by a HPV NAAT screening test would be reflexed to cytology for routine examination.