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Assessment of Serotype-Specific Streptococcus pneumoniae Antibodies



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October 2013

Streptococcus pneumoniae vaccines have been effective in reducing incidence of respiratory and invasive pneumococcal diseases. Quantitative measurement of IgG antibodies against polysaccharides present in these vaccines is useful in assessing the response to active immunization with nonconjugated and protein-conjugated vaccines and determining the ability of an individual to respond to the polysaccharide antigens. Assessment of serotype-specific Streptococcus pneumoniae antibodies is generally only needed as part of an evaluation for humoral or combined immunodeficiency, and not for routine assessment of vaccine responses.

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