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Published: September 2013
Hot Topic Q&A is an opportunity for viewers to submit questions to the Hot Topic presenter. The opportunity to submit questions for this topic is now closed.
The following questions were submitted by viewers and answered by the presenter, Dora M. Lam-Himlin, MD, Senior Associate Consultant, Division of Anatomic Pathology and Assistant Professor of Laboratory Medicine and Pathology at Mayo Clinic in Arizona.
Questions are presented as submitted (unedited).
This is correct – donor cells attack the recipient tissue in GVHD.
After bone marrow transplantation, T cells present in the graft perceive the host tissues as antigenically foreign and attack the tissues of the recipient. The T cells produce an excess of cytokines, including tumor necrosis factor-alpha (TNF-α) and interferon-gamma (INF-γ), which results in destruction of host cells.