Acute Promyelocytic Leukemia with t(15;17)(q24;q21); PML-RARA
Optimizing Laboratory Testing for Hematologic Disorders Series
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Dr. Reichard discusses the appropriate utilization of laboratory testing in diagnosis of acute promyelocytic leukemia (APL) with t(15;17)(q24;q21); PML-RARA. APL can often be differentiated from other types of AML based on bone marrow morphology, but the genetic aberration is diagnostic. Important laboratory assays include cytochemistry, flow cytometry, conventional cytogenetics, and PML-RARA identification by RT-PCR and FISH.
- Kaaren Reichard, MD
- Consultant in the Division of Hematopathology at Mayo Clinic in Rochester, Minnesota
- 5434 Hematopathology Consultation
- LCMS/3287 Leukemia/Lymphoma immunophenotyping by Flow Cytometry
- BM/8506 Chromosome Analysis, Hematologic Disorders, Bone Marrow
- PMLR/84114 PML/RARA Quantitative, PCR
- FAML/87894 Acute Myeloid Leukemia (AML), FISH: PML/RARA only
Hematologic Disorders Series
- Hot Topic: Leukocyte Alkaline Phosphatase Stain (LAP) - Optimizing Laboratory Testing for Hematologic Disorders Series
- Hot Topic: Classic Myeloproliferative Neoplasms
- Hot Topic: Bone Marrow Genetic Studies for Malignant Lymphoma Staging
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