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Acute Promyelocytic Leukemia with t(15;17)(q24;q21); PML-RARA

Optimizing Laboratory Testing for Hematologic Disorders Series



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May 2013

Dr. Reichard discusses the appropriate utilization of laboratory testing in diagnosis of acute promyelocytic leukemia (APL) with t(15;17)(q24;q21); PML-RARA. APL can often be differentiated from other types of AML based on bone marrow morphology, but the genetic aberration is diagnostic. Important laboratory assays include cytochemistry, flow cytometry, conventional cytogenetics, and PML-RARA identification by RT-PCR and FISH.

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Related Tests

Hematologic Disorders Series

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