Introduction to Severe Combined Immunodeficiencies (SCID) and Newborn Screening for SCID

March 2013

Once diagnosed accurately, newborns with SCID/T cell lymphopenia can appropriate management including life-sustaining treatment. Delays in identification of affected infants rapidly reduce the success of such treatments and significantly increase mortality. In Part 2 of this 2-part presentation, Dr. Abraham discusses the use of appropriate laboratory tests and test interpretation tools for follow-up of abnormal newborn screen for SCID/T cell lymphopenia cases.

Presenter:

• Roshini Abraham, PhD
  • Associate Professor of Laboratory Medicine/Pathology and Medicine at Mayo Clinic
  • Consultant in the Division of Clinical Biochemistry and Immunology at Mayo Clinic in Rochester, Minnesota
  • Director of the Cellular and Molecular Immunology Laboratory within the Department of Laboratory Medicine and Pathology
  • Director of the Jeffrey Modell Foundation for Primary Immunodeficiencies Diagnostic and Research Center at the Mayo Clinic

The SCID Series

• Hot Topic: Introduction to Severe Combined Immunodeficiencies (SCID) and Newborn Screening for SCID, Part 1
• Hot Topic: Introduction to Severe Combined Immunodeficiencies (SCID) and Newborn Screening for SCID, Part 2

Related Tests

• TREC/87959 T-Cell Receptor Excision Circles (TREC) Analysis for Immune Reconstitution
• CD4RT/89504 CD4 T-Cell Recent Thymic Emigrants (RTE)
• TBBS/9336 T- and B-Cell Quantitation by Flow Cytometry
• LPMGF/60591 Lymphocyte Proliferation to Mitogens, Blood
• TCP/89319 T-Cell Subsets, Naive, Memory and Activated

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Forward to a Colleague

Share this presentation with:

• Pediatricians
• Immunologists
• General Practitioners
• Laboratorians

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