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Bone Marrow Genetic Studies for Malignant Lymphoma Staging

Optimizing Laboratory Testing for Hematologic Disorders Series

Published: January 2013

Hot Topic Q&A is an opportunity for viewers to submit questions to the Hot Topic presenter. The opportunity to submit questions for this topic is now closed.

The following questions were submitted by viewers and answered by the presenter, Paul J. Kurtin, MD, Consultant in the Division of Hematopathology, Department of Laboratory Medicine and Pathology at Mayo Clinic in Rochester, Minnesota.

Questions are presented as submitted (unedited).

  1. How may I get a printed copy of the presentation?

    You may open the “Read” tab and print directly from the Mayo Medical Laboratories website.

  2. Does Mayo Clinic currently have a protocol in place for all stem cell and bone marrow donors in regards to screening their stem cell and bone marrow to rule out cytogenetic abnormalities prior to donating their stem cells or bone marrow?

    (Answer provided by Dennis Gastineau, MD, Hematology Division Chair, Mayo Clinic in Rochester, Minnesota. Dr. Gastineau is also involved in the bone marrow transplant program and transfusion medicine.)

    Screening is done with routine blood tests. If there are no abnormalities and no familial disorders, we DON’T usually perform cytogenetics or other sophisticated testing.

    National Marrow Donor Program (NMDP) does questionnaires and routine CBC testing along with HLA, but not actual cytogenetics.

    Allogeneic donors take the same questionnaire as blood donors to screen for risks. In addition, they undergo a physical examination and have CBC, chemistries as well as infectious disease testing performed.