Warfarin Effectiveness Study (MM-WES)
Genotyping Reduces Risk of Hospitalization
Featured Topic Archive
March 2010
Medco Health Solutions, Inc., and Mayo Clinic jointly evaluated the medical, clinical and cost-savings potential of genetic testing, while improving patient safety and care.
This national study conducted in the U.S., compared patient outcomes when Warfarin (a widely used blood thinner) was dosed using pharacogenomic and clinical factors versus just clinical factors.
Resources
Medco, Mayo Clinic Study Reveals Using a Simple Genetic Test Reduces
Hospitalization Rates by Nearly a Third for Patients on
Widely Prescribed Blood Thinner
Medco Health Solutions, Inc. and Mayo Clinic Joint Press Release (March 16, 2010)
Warfarin Sensitivity Genotyping: A Review of the Literature and Summary of Patient Experience
Mayo Clinic Proceedings - Thomas Moyer, PhD, December 2009; 84(12):1079-1094
Warfarin Sensitivity Genotyping: Why? When? How to Use It to Best Advantage
Mayo Clinic Medical Grand Rounds video (47 minutes) –
Robert D. McBane, MD, Thomas Moyer, PhD, and Dennis O'Kane, PhD (March 2010)
Mayo Clinic News Blog
Thomas Moyer, PhD, from Mayo Clinic's Department of Laboratory Medicine and Pathology, offers background on the blood-thinner Warfarin and why genetic variations in patients affect the dose that will be needed to prevent both blood clots and possible side effects, such as excessive bleeding.
Warfarin: Genotyping and Improving Dosing
Mayo Medical Laboratories Communiqué article (August 2008)
Warfarin Sensitivity Genotyping
Mayo Medical Laboratories Hot Topic - Dennis O'Kane, PhD
Mayo Validation Support Services (MVSS)
MVSS assists pharmaceutical, biotechnology and diagnostic companies in the preclinical validation of promising targets, lead compounds, biomarkers and tests. MVSS provided study project management services for the Medco and Mayo Clinic study.
American College of Cardiology
Warfarin Effectiveness Study (MM-WES): Genotyping Reduces Risk of Hospitalization released at annual conference (March 16, 2010)
Medco Research Institute™
Medco Research Institute™ is dedicated to translating science into clinical practice through research initiatives and the application of research results. With an emphasis on comparative effectiveness research, Medco Research Institute conducts programs and research studies primarily in the areas of chronic disease pharmacy care and personalized medicine. The research is powered by Medco’s extensive medical and pharmacy claims database and led by researchers from the Medco Therapeutic Resource Centers® and its personalized medicine division. The purpose of these research efforts is to address public health issues, inform public debate, and ultimately lower the cost and improve the quality of healthcare.
Warfarin - Wikipedia entry
Mayo Medical Laboratories Test Offering
Mayo Test ID 60529: Warfarin Sensitivity Genotype by Sequence Analysis, Blood
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