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Differential Analysis for Thrombotic Microangiopathy (TMA)

Facilitate prompt diagnosis and management of patients with TMA



September 2012

Featured Tests

These featured tests are the tests most frequently associated with TMA:

  • ADAMTS13 Activity and Inhibitor Profile
    ADAMTS13 testing is useful for assisting with the diagnosis of congenital or acquired thrombotic thrombocytopenic purpura. Testing begins with ADAMTS13 activity assay to evaluate the percent activity. If the activity is decreased, an inhibitor screen will be performed to look for specific ADAMTS13 inhibition. If specific inhibition is apparent, the titer of the inhibitor will be determined.
    Analytic Time: ADAMTS13 Activity: 1 day
    Days Performed: Monday through Sunday
  • Shiga Toxin, Molecular Detection, PCR, Feces
    If a patient presents with diarrhea, consider ordering Shiga toxin testing at the same time as the ADAMTS13 profile. Shiga toxin PCR is a sensitive, specific, and rapid test for the detection of the presence of Shiga toxin-producing organisms such as Escherichia coli O157:H7 and Shigella dysenteriae type 1 in stool. Unlike enzyme immunoassays and many other PCR assays targeting Shiga toxin, the real-time PCR assay done at Mayo Clinic can be performed directly on stool, without an enrichment step. This means that the results of testing are available the same day the specimen arrives into the laboratory—a significant benefit in turnaround time.
    Analytic Time: Shiga Toxin: 1 day
    Days Performed: Monday through Sunday
  • C3 Complement, Functional, Serum
    C4 Complement, Functional, Serum

    Complement testing can assist in diagnosis of C3 or C4 deficiency as well as investigation of a patient with undetectable alternative pathway function. Complement testing should be drawn before plasma exchange occurs. A frozen specimen can be stable up to 14 days.
    Analytic Time: 1 day
    Days Performed: Monday through Saturday

For More Information

For more information on how our testing can help facilitate prompt diagnosis and management of patients with TMA, contact your Regional Manager.


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