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Plasma Cell Disorders

Improving patient diagnosis and treatment

December 2012

What is Amyloidosis?

Amyloidosis is a systemic disease characterized by abnormal deposition of cellular proteins in extracellular sites in a physical form that is resistant to normal degradation processes. The disease is often systemic and life threatening, frequently affecting vital organs such as the kidneys or the heart.

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Accurate Subtyping of Amyloidosis

At least 25 different proteins have been shown to cause amyloidosis and the underlying pathogenesis of each subtype of amyloidosis is unique. The treatment approach for each subtype of amyloidosis may be radically different. Mayo Clinic has developed a novel diagnostic methodology that can subtype amyloidosis in routine biopsy specimens with high accuracy. The method combines specific sampling of the amyloid plaques by laser microdissection and the analytical power of tandem mass spectrometry-based proteomic analysis.

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For More Information

For more information on our amyloidosis protein identification, contact your Regional Manager.