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Mycobacteria

Comprehensive Testing for Identification and Susceptibility




May 2013

CLSI Guidelines

The Clinical and Laboratory Standards Institute (CLSI) is a not-for-profit membership organization whose mission is to develop clinical and laboratory practices and promote their use worldwide.

Mayo Clinic’s Mycobacteriology Laboratory follows CLSI guidelines and utilizes these interpretive criteria for determination of resistant strains.

View a comparison of our susceptibility panels and CLSI guidelines:

Mycobacterium tuberculosis


Primary Agents

Second-Line Agent
  • Amikacin
  • Cycloserine
  • Ethionamide
  • Kanamycin
  • Moxifloxacin
  • Ofloxacin
  • P-aminosalicylic acid (PAS)
  • Rifabutin
  • Streptomycin

 

Slowly growing NTM


Mycobacterium avium Complex

Primary Agent
  • Clarithromycin

Second-Line Agent
  • Linezolid
  • Moxifloxacin

Other Agent
  • Ethambutol
  • Isoniazid
  • Rifampin
  • Streptomycin
  • Amikacin
  • Ciprofloxacin
  • Doxycycline
  • Trimethoprim / Sulfamethoxazole
  • Ethionamide
  • Rifabutin

Mycobacterium kansasii & Miscellaneous Nonfastidious NTM's

Primary Agent
  • Clarithromycin
  • Rifampin

Second-Line Agent
  • Amikacin
  • Ciprofloxacin
  • Ethambutol
  • Isoniazid
  • Linezolid
  • Moxifloxacin
  • Rifabutin
  • Streptomycin
  • Trimethoprim / Sulfamethoxazole


Mycobacterium marinum

Primary Agent
  • Amikacin
  • Ciprofloxacin
  • Clarithromycin
  • Doxycycline / Minocyclinel
  • Ethambutol
  • Moxifloxacin
  • Rifabutin
  • Rifampin
  • Trimethoprim / Sulfamethoxazole

 

Rapidly growing NTM


Primary Agent
  • Amikacin
  • Cefoxitin
  • Ciprofloxacin
  • Clarithromycin
    • 14 day incubation of clarithromycin
      for erm gene induction
  • Doxycycline
  • Imipenem
  • Linezolid
  • Meropenem
  • Moxifloxacin
  • Trimethoprim / Sulfamethoxazole
  • Tobramycin
  • Tigecycline

 

Aerobic Actinomycetes


Primary Agent
  • Amikacin
  • Amoxicillin / Clavulanic Acid
  • Ceftriaxone
  • Ciprofloxacin
  • Clarithromycin
  • Imipenem
  • Linezolid
  • Minocycline
  • Moxifloxacin
  • Trimethoprim / Sulfamethoxazole
  • Tobramycin

Second-Line Agent
  • Cefepime
  • Cefotaxime
  • Doxycycline

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