Testing of Hematopoietic Neoplasms
Featured Topic Archive
- Communiqué: How to Interpret and Pursue an Abnormal Complete Blood Cell Count in Adults
- Communiqué: A Combined Cytoplasmic Immunoglobulin Staining and FISH Method (cIg FISH) to Detect Prognostic Genetic Anomalies in Multiple Myeloma and Related Plasma Cell Proliferative Disorders
- Communiqué: Polycythemia Vera
- Communiqué: FISH Analysis Provides Important Prognostic Information in B-Cell Chronic Lymphocytic Leukemia
- Mayo Clinic Video: Polycythemia Vera (PV)
- Mayo Clinic Video: Updated mSMART Consensus Guidelines for Myeloma
- Hot Topic: Leukocyte Alkaline Phosphatase Stain (LAP) - Optimizing Laboratory Testing for Hematologic Disorders Series
updated April 2012
What are Hematopoietic Neoplasms?
Hematopoietic neoplasms are clonal disorders of hematopoietic cells, which constitute red cells, white cells, and platelets. They typically manifest as leukemias, lymphomas, and plasma cell disorders. Leukemias predominantly involve peripheral blood and bone marrow, while lymphomas involve tissue-based sites such as lymph nodes, stomach, or skin.
Challenges in the Accurate Diagnosis of Hematopoietic Neoplasms
As technologies have advanced beyond typical chromosome analysis to include FISH- and PCR-based testing, accurate and cost-effective diagnosis of hematopoietic neoplasms has become much more challenging for clinicians and pathologists.
To address these challenges, Mayo Clinic clinicians and pathologists work together to establish unique test guidelines, algorithms, and specimen submission options that best utilize these technologies to provide the right diagnosis for the right patient.
Featured Hot Topic
The Classic Myeloproliferative Neoplasms: Optimizing Laboratory Testing for Hematologic Disorders
Curtis A. Hanson, MD, addresses guidelines for appropriate laboratory test utilization in hematologic disorders that represent the combined effort of the Divisions of Hematopathology and Laboratory Genetics.
These featured algorithms discuss diagnostic testing for myeloproliferative neoplasms:
- Myeloproliferative Neoplasm: A Diagnostic Approach to Peripheral Blood Evaluation
- Myeloproliferative Neoplasm: A Diagnostic Approach to Bone Marrow Evaluation
These featured tests are the tests most frequently associated with hematopoietic neoplasms:
- Hematopathology Consultation
- Leukemia/Lymphoma Immunophenotyping by Flow Cytometry
- Hematologic Disorders, Leukemia/Lymphoma; Flow Hold Varies
- Chromosome Analysis, Hematologic Disorders, Bone Marrow
- BCR/ABL, mRNA Detection, Reverse Transcription-PCR (RT-PCR), Qualitative, Diagnostic Assay
- BCR/ABL, Translocation 9;22, FISH (D-FISH)
- Erythropoietin (EPO), Serum
- JAK2 V617F Mutation Detection: Blood | Bone Marrow
- JAK2 Exon 12 and Other Non-V617F Mutation Detection: Blood | Bone Marrow
- MPL Exon 10 Mutation Detection: Blood | Bone Marrow