Testing of Hematopoietic Neoplasms

updated April 2012

What are Hematopoietic Neoplasms?

Hematopoietic neoplasms are clonal disorders of hematopoietic cells, which constitute red cells, white cells, and platelets. They typically manifest as leukemias, lymphomas, and plasma cell disorders. Leukemias predominantly involve peripheral blood and bone marrow, while lymphomas involve tissue-based sites such as lymph nodes, stomach, or skin.

Challenges in the Accurate Diagnosis of Hematopoietic Neoplasms

As technologies have advanced beyond typical chromosome analysis to include FISH- and PCR-based testing, accurate and cost-effective diagnosis of hematopoietic neoplasms has become much more challenging for clinicians and pathologists.

To address these challenges, Mayo Clinic clinicians and pathologists work together to establish unique test guidelines, algorithms, and specimen submission options that best utilize these technologies to provide the right diagnosis for the right patient.

Resources

Featured Hot Topic

The Classic Myeloproliferative Neoplasms: Optimizing Laboratory Testing for Hematologic Disorders
Curtis A. Hanson, MD, addresses guidelines for appropriate laboratory test utilization in hematologic disorders that represent the combined effort of the Divisions of Hematopathology and Laboratory Genetics.

 

 

Featured Algorithms

These featured algorithms discuss diagnostic testing for myeloproliferative neoplasms:

• Myeloproliferative Neoplasm: A Diagnostic Approach to
  Peripheral Blood Evaluation
• Myeloproliferative Neoplasm: A Diagnostic Approach to
  Bone Marrow Evaluation
• More

Featured Disease Management Strategy

Molecular Evaluation of BCR/ABL1 in Chronic Myelogenous Leukemia (CML)
With multiple tests for this target available at Mayo Clinic, each designed for a specific need, it can be confusing which to order and when.

This Disease Management Strategies presentation discusses each of the currently available tests and how they are best used together for clinical management of CML patients.

View a preview of the presentation...

Featured Tests

These featured tests are the tests most frequently associated with hematopoietic neoplasms:

• Hematopathology Consultation (Test ID: 5434)


• Leukemia/Lymphoma Immunophenotyping by Flow Cytometry (Test ID: LCMS)


• Hematologic Disorders, Leukemia/Lymphoma; Flow Hold Varies (Test ID: HLLFH)


• Chromosome Analysis, Hematologic Disorders, Bone Marrow (Test ID: BM)


• BCR/ABL, mRNA Detection, Reverse Transcription-PCR (RT-PCR),
  Qualitative, Diagnostic Assay (Test ID: BADX)


• BCR/ABL, Translocation 9;22, FISH (D-FISH) (Test ID: MCBR)


• Erythropoietin (EPO), Serum (Test ID: EPO)


• JAK2 V617F Mutation Detection: Blood (Test ID: JAK2B) | Bone Marrow (Test ID: JAK2M)
• JAK2 Exon 12 and Other Non-V617F Mutation Detection: Blood (Test ID: JAKXB) | Bone Marrow (Test ID: JAKXM)
• MPL Exon 10 Mutation Detection: Blood (Test ID: MPLB) | Bone Marrow (Test ID: MPLM)

To view a comprehensive test menu for hematopoietic diseases, see our hematology test catalog.