Updated: December 2014
Published: December 2012
Management and Diagnosis of Erythrocytosis
The testing options for general erythrocytosis greatly benefit from
an algorithmic and reflexive approach for a cost-effective and
- Most cases are due to polycythemia vera, and
knowledge of the JAK2 V617F status is an optimal place to begin.
- Additionally, the serum erythropoietin level allows stratification
of JAK2 V617F negative cases.
- If the serum erythropoietin level
is normal or elevated, testing for oxygen dissociation, p50 helps
further define the process and suggests the most likely potential
etiologies and the best testing strategy.
- When polycythemia vera
and acquired causes of erythrocytosis are excluded and the p50
value is normal, an evaluation for hereditary erythrocytosis should