New Test Algorithms for Celiac Disease
An Efficient and Cost-Effective Diagnostic Approach
Featured Topic Archive
Updated: June 2013
Mayo Medical Laboratories' test algorithms for celiac disease use a reflex approach that provides a cost-effective alternative to ordering individual tests when evaluating a patient with suspected celiac disease. The goal of these algorithms is to provide the most appropriate selection of tests for each patient, while maintaining the highest possible sensitivity and specificity.
The following Hot Topic presentations discuss the algorithmic approach to diagnostic testing for celiac disease.
Melissa Snyder, Ph.D., Director of the Antibody Immunology Laboratory in the Division of Clinical Biochemistry and Immunology at Mayo Clinic, discusses the new celiac disease panels available from Mayo Medical Laboratories and the algorithmic approach of each.
Joseph Murray, M.D., a practicing gastroenterologist and Professor of Medicine and Immunology at Mayo Clinic, as well as Director of Mayo’s Celiac Disease Program, discusses several cases of celiac disease and the appropriate diagnostic testing for each situation.
- Includes both serologic and genetic testing (HLA DQ typing)
- Most complete assessment that can be ordered
- Can virtually rule-out celiac disease in most patients
- Includes individual test results, clinical interpretation and recommendations on whether to proceed to biopsy or pursue another diagnosis
- Available when HLA DQ typing is not desired or has been performed previously
- Interpretive report includes recommendations on the need for confirmatory biopsy
- Developed to assist in evaluating patients who have already reduced gluten in their diet
- Includes HLA DQ typing as the initial test
- Developed to assist in patient care
- Assesses IgA or IgG antibodies to determine patient’s adherence to gluten-free diet
- Available for those who prefer to order tests individually