Test Catalog

New Test Algorithms for Celiac Disease

An Efficient and Cost-Effective Diagnostic Approach

Updated: June 2013

Mayo Medical Laboratories' test algorithms for celiac disease use a reflex approach that provides a cost-effective alternative to ordering individual tests when evaluating a patient with suspected celiac disease. The goal of these algorithms is to provide the most appropriate selection of tests for each patient, while maintaining the highest possible sensitivity and specificity.

The following Hot Topic presentations discuss the algorithmic approach to diagnostic testing for celiac disease.

Hot Topic

Click CC box for captions; full transcript is below.

Melissa Snyder, Ph.D., Director of the Antibody Immunology Laboratory in the Division of Clinical Biochemistry and Immunology at Mayo Clinic, discusses the new celiac disease panels available from Mayo Medical Laboratories and the algorithmic approach of each.

Clinical Insight

Click CC box for captions; full transcript is below.

Joseph Murray, M.D., a practicing gastroenterologist and Professor of Medicine and Immunology at Mayo Clinic, as well as Director of Mayo’s Celiac Disease Program, discusses several cases of celiac disease and the appropriate diagnostic testing for each situation.


Celiac Disease Comprehensive Cascade

  • Includes both serologic and genetic testing (HLA DQ typing)
  • Most complete assessment that can be ordered
  • Can virtually rule-out celiac disease in most patients
  • Includes individual test results, clinical interpretation and recommendations on whether to proceed to biopsy or pursue another diagnosis

Celiac Disease Serology Cascade

  • Available when HLA DQ typing is not desired or has been performed previously
  • Interpretive report includes recommendations on the need for confirmatory biopsy

Celiac Disease Comprehensive Cascade for Patients on Gluten-Free Diet

  • Developed to assist in evaluating patients who have already reduced gluten in their diet
  • Includes HLA DQ typing as the initial test

Celiac Disease Routine Treatment Monitoring Algorithm

  • Developed to assist in patient care
  • Assesses IgA or IgG antibodies to determine patient’s adherence to gluten-free diet

Celiac Disease Diagnostic Testing Algorithm

  • Available for those who prefer to order tests individually

White Paper

Update on Celiac Disease: New Standards and New Tests

Frequently Asked Questions

+ What about testing for gliadin antibodies?

+ Should reticulin antibody testing be ordered in the evaluation for celiac disease?

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