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Propoxyphene

Interpretation

The clearance half-life of propoxyphene averages 10 hours. The clearance half-life of norpropoxyphene averages 30 hours. Following a typical 0.2 mg dose of propoxyphene, the drug appears in the urine within 30 minutes. Peak urine output is reached at about 2 hours.

Notes:

  • The presence of propoxyphene >LOQ indicates exposure to propoxyphene for 2 to 3 days prior to specimen collection.
  • The presence of the propoxyphene metabolite norpropoxyphene >LOQ indicates exposure to propoxyphene within 7 to 10 days prior to specimen collection.

Metabolites

  • Propoxyphene is metabolized to norpropoxyphene.

    Propoxyphene Norpropoxyphene

Approximate Detection Times

Propoxyphene LOQ (ng/mL) Detection Time* up to
     Propoxyphene
300
10 days
     Norpropoxyphene
300
3 days
*These are approximate detection times for the drug or metabolites in urine. The actual detection time depends on dose, frequency of use, and individual metabolism.


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