Limits of Detection (LOD) Table —
Prescription and OTC Drugs
Last Updated January 2011
The limits of detections (LODs) listed below reflect the concentrations at which the specific drugs can be reliably detected. If the drug is detected at a level below the listed LOD, it will be reported only if it meets laboratory quality criteria for identification.
Drugs other than those listed below may be detected by GC-MS library matching and will be reported if they meet laboratory quality criteria for identification.
Note: Submission of less than the minimum sample volume requires increasing the limit of detection.
| Generic Name | LOD
(mcg/mL) |
Notes | Urine | Serum |
|---|---|---|---|---|
| Acetaminophen | 10.0 |
|||
| Amitriptyline | 1.0 |
Variability in the LOD |
||
| Amobarbital | 1.0 |
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation | ||
| Bupropion | 1.0 |
|||
| Butabarbital | 1.0 |
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation | ||
| Butalbital | 10.0 |
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation | ||
| Caffeine | 15.0 |
|||
| Carbamazepine | 2.0 |
|||
| Carisoprodol | 5.0 |
|||
| Chlordiazepoxide | 5.0 |
Preferred test for detection of benzodiazepines is a specific request; see Specific Drug Group Confirmation | Variability in the LOD |
|
| Chlorpheniramine | 1.0 |
|||
| Chlorpromazine | 5.0 |
|||
| Chlorpropamide | 5.0 |
|||
| Citalopram | 1.0 |
Unable to differentiate between R- and S-citalopram, reported as citalopram. | Variability in the LOD |
|
| Clomipramine | 1.0 |
Variability in the LOD |
||
| Clozapine | 1.0 |
|||
| Cyclobenzaprine | 1.0 |
|||
| Desipramine | 5.0 |
Variability in the LOD |
Variability in the LOD |
|
| Dextromethorphan | 5.0 |
|||
| Diazepam | 0.5 |
Preferred test for detection of benzodiazepines is a specific request; see Specific Drug Group Confirmation | ||
| Diltiazem | 1.0 |
|||
| Diphenhydramine | 0.5 |
|||
| Doxepin | 1.0 |
Variability in the LOD |
||
| Doxylamine | 5.0 |
|||
| EDDP (methadone metabolite) |
2.5 |
Preferred test for detection of methadone and metabolite is a specific request; see Specific Drug Group Confirmation | Only detected in urine |
|
| Ethosuximide | 5.0 |
|||
| Etomidate | 1.0 |
|||
| Felbamate | 5.0 |
|||
| Fentanyl | 1.0 |
Preferred test for detection of fentanyl is a specific request; see Specific Drug Group Confirmation | ||
| Fluconazole | 5.0 |
|||
| Fluoxetine | 4.0 |
|||
| Gemfibrozil | 5.0 |
|||
| Hydrocodone | 5.0 |
Preferred test for detection of opiates is a specific request; see Specific Drug Group Confirmation | Variability in the LOD |
|
| Hydroxyzine | 5.0 |
Variability in the LOD |
||
| Ibuprofen | 25.0 |
Variability in the LOD |
||
| Imipramine | 0.5 |
Variability in the LOD |
||
| Lamotrigine | 25.0 |
Variability in the LOD |
||
| Lidocaine | 1.0 |
|||
| Lorazepam | 5.0 |
Preferred test for detection of benzodiazepines is a specific request; see Specific Drug Group Confirmation | Variability in the LOD |
|
| Meperidine | 1.0 |
Variability in the LOD |
||
| Mephobarbital | 1.0 |
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation | ||
| Meprobamate | 5.0 |
|||
| Metaxalone | 1.0 |
|||
| Methadone | 1.0 |
Preferred test for detection of methadone is a specific request; see Specific Drug Group Confirmation | Variability in the LOD |
|
| Methocarbamol | 2.5 |
Variability in the LOD |
||
| Methsuximide | 1.0 |
|||
| Methylphenidate | 10.0 |
|||
| Metronidazole | 5.0 |
|||
| Midazolam | 1.0 |
Preferred test for detection of benzodiazepines is a specific request; see Specific Drug Group Confirmation | ||
| Mirtazapine | 1.0 |
|||
| Naproxen | 30.0 |
|||
| Nordiazepam | 1.0 |
|||
| Normethsuximide | 10.0 |
|||
| Norpropoxyphene | 10.0 |
Preferred test for detection of propoxyphene is a specific request; see Specific Drug Group Confirmation | ||
| Nortriptyline | 1.0 |
Variability in the LOD |
||
| Oxcarbazepine Metabolite |
5.0 |
|||
| Paroxetine | 20.0 |
Variability in the LOD |
Variability in the LOD |
|
| Pentazocine | 5.0 |
|||
| Pentobarbital | 5.0 |
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation | ||
| Pentoxifylline | 1.0 |
|||
| Phencyclidine | 1.0 |
Preferred test for detection of PCP is a specific request; see Specific Drug Group Confirmation | ||
| Phenobarbital | 5.0 |
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation | ||
| Phenytoin | 5.0 |
|||
| Primidone | 5.0 |
|||
| Promethazine | 1.0 |
|||
| Propofol | 5.0 |
|||
| Propoxyphene | 0.5 |
Preferred test for detection of propoxyphene is a specific request; see Specific Drug Group Confirmation | ||
| Quetiapine | 5.0 |
Variability in the LOD |
Variability in the LOD |
|
| Quinidine | 5.0 |
Variability in the LOD |
||
| Salicylate | 5.0 |
|||
| Secobarbital | 1.0 |
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation | ||
| Sertraline | 1.0 |
Variability in the LOD |
Variability in the LOD |
|
| Temazepam | 1.0 |
Preferred test for detection of benzodiazepines is a specific request; see Specific Drug Group Confirmation | Variability in the LOD |
|
| Theophylline | 5.0 |
|||
| Thiopental | 1.0 |
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation | ||
| Thioridazine | 1.0 |
|||
| Ticlopidine | 1.0 |
|||
| Topiramate | 5.0 |
|||
| Tramadol | 5.0 |
|||
| Trazodone | 2.0 |
|||
| Trimipramine | 1.0 |
|||
| Valproic Acid | 5.0 |
|||
| Venlafaxine | 2.0 |
|||
| Verapamil | 1.0 |
|||
| Zolpidem | 1.0 |
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