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Limits of Detection (LOD) Table —

Prescription and OTC Drugs

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Last Updated January 2011

The limits of detections (LODs) listed below reflect the concentrations at which the specific drugs can be reliably detected. If the drug is detected at a level below the listed LOD, it will be reported only if it meets laboratory quality criteria for identification.

Drugs other than those listed below may be detected by GC-MS library matching and will be reported if they meet laboratory quality criteria for identification.

Note: Submission of less than the minimum sample volume requires increasing the limit of detection.

Generic Name
LOD (mcg/mL)
Notes Urine Serum
Acetaminophen
10.0
     
Amitriptyline
1.0
  Variability in
the LOD
 
Amobarbital
1.0
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation    
Bupropion
1.0
     
Butabarbital
1.0
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation    
Butalbital
10.0
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation    
Caffeine
15.0
     
Carbamazepine
2.0
     
Carisoprodol
5.0
     
Chlordiazepoxide
5.0
Preferred test for detection of benzodiazepines is a specific request; see Specific Drug Group Confirmation Variability in
the LOD
 
Chlorpheniramine
1.0
     
Chlorpromazine
5.0
     
Chlorpropamide
5.0
     
Citalopram
1.0
Unable to differentiate between R- and S-citalopram, reported as citalopram. Variability in
the LOD
 
Clomipramine
1.0
  Variability in
the LOD
 
Clozapine
1.0
     
Cyclobenzaprine
1.0
     
Desipramine
5.0
  Variability in
the LOD
Variability in
the LOD
Dextromethorphan
5.0
     
Diazepam
0.5
Preferred test for detection of benzodiazepines is a specific request; see Specific Drug Group Confirmation    
Diltiazem
1.0
     
Diphenhydramine
0.5
     
Doxepin
1.0
  Variability in
the LOD
 
Doxylamine
5.0
     
EDDP (methadone
metabolite)
2.5
Preferred test for detection of methadone and metabolite is a specific request; see Specific Drug Group Confirmation   Only detected
in urine
Ethosuximide
5.0
     
Etomidate
1.0
     
Felbamate
5.0
     
Fentanyl
1.0
Preferred test for detection of fentanyl is a specific request; see Specific Drug Group Confirmation    
Fluconazole
5.0
     
Fluoxetine
4.0
     
Gemfibrozil
5.0
     
Hydrocodone
5.0
Preferred test for detection of opiates is a specific request; see Specific Drug Group Confirmation Variability in
the LOD
 
Hydroxyzine
5.0
  Variability in
the LOD
 
Ibuprofen
25.0
  Variability in
the LOD
 
Imipramine
0.5
  Variability in
the LOD
 
Lamotrigine
25.0
  Variability in
the LOD
 
Lidocaine
1.0
     
Lorazepam
5.0
Preferred test for detection of benzodiazepines is a specific request; see Specific Drug Group Confirmation Variability in
the LOD
 
Meperidine
1.0
  Variability in
the LOD
 
Mephobarbital
1.0
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation    
Meprobamate
5.0
     
Metaxalone
1.0
     
Methadone
1.0
Preferred test for detection of methadone is a specific request; see Specific Drug Group Confirmation Variability in
the LOD
 
Methocarbamol
2.5
  Variability in
the LOD
 
Methsuximide
1.0
     
Methylphenidate
10.0
     
Metronidazole
5.0
     
Midazolam
1.0
Preferred test for detection of benzodiazepines is a specific request; see Specific Drug Group Confirmation    
Mirtazapine
1.0
     
Naproxen
30.0
     
Nordiazepam
1.0
     
Normethsuximide
10.0
     
Norpropoxyphene
10.0
Preferred test for detection of propoxyphene is a specific request; see Specific Drug Group Confirmation    
Nortriptyline
1.0
  Variability in
the LOD
 
Oxcarbazepine
Metabolite
5.0
     
Paroxetine
20.0
  Variability in
the LOD
Variability in
the LOD
Pentazocine
5.0
     
Pentobarbital
5.0
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation    
Pentoxifylline
1.0
     
Phencyclidine
1.0
Preferred test for detection of PCP is a specific request; see Specific Drug Group Confirmation    
Phenobarbital
5.0
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation    
Phenytoin
5.0
     
Primidone
5.0
     
Promethazine
1.0
     
Propofol
5.0
     
Propoxyphene
0.5
Preferred test for detection of propoxyphene is a specific request; see Specific Drug Group Confirmation    
Quetiapine
5.0
  Variability in
the LOD
Variability in
the LOD
Quinidine
5.0
  Variability in
the LOD
 
Salicylate
5.0
     
Secobarbital
1.0
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation    
Sertraline
1.0
  Variability in
the LOD
Variability in
the LOD
Temazepam
1.0
Preferred test for detection of benzodiazepines is a specific request; see Specific Drug Group Confirmation Variability in
the LOD
 
Theophylline
5.0
     
Thiopental
1.0
Preferred test for detection of barbiturates is a specific request; see Specific Drug Group Confirmation    
Thioridazine
1.0
     
Ticlopidine
1.0
     
Topiramate
5.0
     
Tramadol
5.0
     
Trazodone
2.0
     
Trimipramine
1.0
     
Valproic Acid
5.0
     
Venlafaxine
2.0
     
Verapamil
1.0
     
Zolpidem
1.0
     

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