New Tests

May 2013

New tests are continually developed by the clinical and research laboratories of Mayo Clinic. These tests are subjected to an intense laboratory and clinical correlative process to ensure their diagnostic utility prior to their release.

Significant new test announcements are included with each Communiqué issue to provide both clinical and technical information in a single document.

The following tests are described in this month's Communiqué:

PPAN/50255 Acute Porphyria, Multi-Gene Panel

• Useful for: Confirmation of acute porphyria for patients with clinical features of the disease ....more>>

MMLSG/34805 Antimicrobial Susceptibility, Acid-Fast Bacilli, Slowly Growing

• Useful for: Determination of resistance of rapidly growing mycobacteria to antimicrobial agents ...more>>

DCP/61844 Des-Gamma-Carboxy Prothrombin (DCP), Serum

• Useful for: Risk assessment of patients with chronic liver disease for development of hepatocellular carcinoma (HCC) ...more>>

FACT/61620 F-Actin Ab, IgG, S

• Useful for: Evaluating patients suspected of having autoimmune hepatitis ...more>>

F2ISO/88677 F2-Isoprostanes, Urine

• Useful for: The assessment of in vivo lipid peroxidation and considered to be an index of systemic oxidative stress over time ...more>>

HIV2L/61785 HIV-2 Antibody Confirmation, Serum

• Useful for: Confirmation of presence of HIV-2 antibodies in serum with repeatedly reactive combined HIV-1/-2 or HIV-2 antibody-only screening serologic test results, diagnosis of HIV-2 infection ...more>>

HURLS/61481 Hurler Syndrome, Full Gene Analysis

• Useful for: Identifying mutations within the IDUA gene, Confirmation of a diagnosis of mucopolysaccharidosis type I (MPS-I) ...more>>

HURLK/61482 Hurler Syndrome, Known Mutation

• Useful For: Carrier testing of individuals with a family history of mucopolysaccharidosis type I (MPS-I), diagnostic confirmation of MPS-I when familial mutations have been previously identified ...more>>

EGFRX/61860 Lung Cancer, EGFR with ALK Reflex, Tumor

• Useful For: Identifying non-small cell lung cancers that may benefit from treatment with epidermal growth factor receptor-tyrosine kinase or anaplastic lymphoma kinase inhibitors ...more>>

PLSD/89678 Lysosomal and Peroxisomal Storage Disorders Screen, Blood Spot

• Useful For: Evaluation of patients with a clinical presentation suggestive of a lysosomal storage disorder, specifically Gaucher, Niemann-Pick type A or type B, Pompe, Krabbe, Fabry disease, or mucopolysaccharidosis I; or a peroxisomal disorder, either X-linked adrenoleukodystrophy or Zellweger spectrum syndrome ...more>>

FMEL/61833 Melanoma, FISH, Tissue

• Useful For: This test is intended to be used in conjunction with clinical and pathologic information to aid the pathologist in the differentiation of benign from malignant melanocytic lesions ...more>>

MLHBL/61841 MLH1 Hypermethylation Analysis, Blood

• Useful For: An adjunct to positive hypermethylation in tumor to distinguish between somatic and germline hypermethylation, An adjunct to negative MLH1 germline testing in cases where colon or endometrial tumor demonstrates microsatellite instability-H and loss of MLH1 protein expression ...more>>

PPOXS/61261 PPOX Gene, Full Gene Analysis

• Useful For: Confirmation of variegate porphyria for patients with clinical and biochemical features of the disease, identification of familial PPOX mutation to allow for genetic testing in family members ...more>>

PPOXK/61262 PPOX Gene, Known Mutation

• Useful For: Predictive testing for variegate porphyria when a PPOX mutation has been identified in an affected family member ...more>>

TPNI/81767 Troponin I, Serum

• Useful For: Exclusion diagnosis of acute myocardial infarction ...more>>