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HIV-1 Testing Change and Algorithm Update


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October 2008

A single assay, #81958 HIV Type 1 RNA Quantification, Plasma, has replaced both the standard and ultrasensitive HIV-1 viral load assays (#80928 HIV Type 1 RNA Standard Quantification, Plasma and #81624 HIV Type 1 Ultra-Sensitive Quantification, Plasma) previously offered at Mayo Medical Laboratories. By using state-of-the-art, real-time, reverse transcription-PCR technology, this new FDAapproved assay quantifies HIV-1 RNA in human plasma in the range of 48 to 10,000,000 copies/mL (1.68 to 7.00 log copies/mL). Test results are reported in both integer and logarithmic values to facilitate comparison of serial test results in a given patient.

In addition, the reflex test offering, #88633 HIV Type 1 RNA Ultra-Sensitive Quantification with Reflex to HIV-1 Genotype Drug Resistance Mutation Analysis, Plasma, has been replaced with #13035 HIV Type 1 RNA Standard Quantification with Reflex to HIV-1 Genotypic Drug Resistance Mutation Analysis, Plasma. Test #13035 begins with the new quantification assay (#81958) and proceeds to HIV-1 genotypic drug resistance testing when the HIV-1 RNA level is ≥1,000 copies/mL.

A revised HIV Treatment Monitoring Algorithm is included for your reference:


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