Biliary Tract Malignancy

Introduction

September 2011

Welcome to Mayo Medical Laboratories. These presentations provide short discussions of current topics and may be helpful to you in your practice.

Our presenters for this program are from Mayo Clinic in Rochester, Minnesota. Dr. Gregory Gores is chair of the Division of Gastroenterology and Hepatology and Professor of Medicine and Physiology in the College of Medicine and Dr. Kevin Halling is vice chair for research and development for the Department of Laboratory Medicine and Pathology and consultant in the Division of Laboratory Genetics. Dr. Gores will discuss the clinical aspects of biliary tract malignancy and present case studies and Dr. Halling will explain the laboratory testing available to assist in diagnosis. Dr. Gores will start off this presentation. Thank you both, Dr. Gores and Dr. Halling.

Introduction

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Jump to section:

• Disclosures
• Pancreatobiliary Strictures (PBS)
• Primary Sclerosing Cholangitis (PSC)
• Pancreatobiliary Strictures (PBS)
• Bile Duct Brushings
• Current Clinical Practice
• Factors That Influence Sensitivity Of Cytology Specimens
• Routine Cytology
• Cancer Is A Genetic Disorder That Results From Mutations
• Detecting Tumor Cells in Cytology Specimens Using FISH
• Types of FISH Probes
• FISH
• Sensitivity and Specificity of Various Tests for Detection of Pancreatobiliary Strictures Malignancy
• What Do We Do With These Data?
• Bile Duct Pathology Calculator
• Representative Test Report Using Bile Duct Calculator
• Bile Duct Calculator
• Impact of Disease Prevalence on Positive Predictive Value (PPV)
• Case 1
• Case 1 Cytologic Findings
• Case 1
• Case 1 Test Report Using Bile Duct Calculator
• Case 1
• Case 1
• Case 2
• Case 2 Cytologic Findings
• Case 2
• Case 2: Test Report Using Bile Duct Calculator
• Case 2
• Case 2
• Case 3
• Case 3 Cytologic Findings
• Case 3
• Case 3
• Case 3: Test Report Using Bile Duct Calculator
• Case 3
• Case 3
• Summary
• Summary
• Results
• Questions?